Eugene Braunwald Selected Research

Simvastatin Drug Combination Ezetimibe (Vytorin)

10/2021	Baseline Low-Density Lipoprotein Cholesterol and Clinical Outcomes of Combining Ezetimibe With Statin Therapy in IMPROVE-IT.
9/2020	Prospective Evaluation of Malignancy in 17,708 Patients Randomized to Ezetimibe Versus Placebo: Analysis From IMPROVE-IT.
1/2019	Medication Discontinuation in the IMPROVE-IT Trial.
12/2018	Response by Bohula et al to Letters Regarding Article, "Prevention of Stroke With the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary Syndrome in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)".
10/2018	Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Safety in Patients With Versus Without Diabetes Mellitus: Results From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).
12/2017	Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary Syndrome in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).
11/2017	Efficacy and Safety of Adding Ezetimibe to Statin Therapy Among Women and Men: Insight From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).
1/2017	Impact of Ezetimibe on the Rate of Cardiovascular-Related Hospitalizations and Associated Costs Among Patients With a Recent Acute Coronary Syndrome: Results From the IMPROVE-IT Trial (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).
1/2017	Long-term Safety and Efficacy of Achieving Very Low Levels of Low-Density Lipoprotein Cholesterol : A Prespecified Analysis of the IMPROVE-IT Trial.
2/2016	Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome: The IMPROVE-IT Trial.

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Eugene Braunwald Research Topics

Disease

264	Myocardial Infarction 10/2022 - 02/2002
173	Acute Coronary Syndrome 01/2022 - 02/2002
118	Stroke (Strokes) 09/2022 - 04/2004
112	Hemorrhage 09/2022 - 02/2002
104	Heart Failure 01/2022 - 03/2002
64	ST Elevation Myocardial Infarction 01/2022 - 03/2002
52	Atrial Fibrillation 09/2022 - 09/2010
44	Thrombosis (Thrombus) 01/2021 - 07/2002
34	Ischemia 10/2018 - 07/2003
33	Diabetes Mellitus 11/2021 - 10/2002
29	Coronary Artery Disease (Coronary Atherosclerosis) 12/2021 - 11/2002
29	Unstable Angina 02/2016 - 02/2002
23	Ischemic Stroke 11/2020 - 09/2009
20	Coronary Disease (Coronary Heart Disease) 01/2018 - 03/2002
19	Cardiovascular Diseases (Cardiovascular Disease) 03/2022 - 04/2002
19	Infections 04/2018 - 04/2002
17	Embolism (Embolus) 09/2022 - 10/2010
17	Atherosclerosis 03/2022 - 02/2003
17	Intracranial Hemorrhages (Intracranial Hemorrhage) 04/2021 - 04/2003
17	Type 2 Diabetes Mellitus (MODY) 01/2020 - 11/2011
16	Hypertension (High Blood Pressure) 01/2021 - 02/2003
16	Infarction (Infarctions) 10/2016 - 04/2002
15	Peripheral Arterial Disease 09/2022 - 08/2004
14	Non-ST Elevated Myocardial Infarction 08/2014 - 02/2002
10	Transient Ischemic Attack 11/2020 - 10/2011
9	Body Weight (Weight, Body) 01/2022 - 03/2005
9	Fibrosis (Cirrhosis) 01/2021 - 01/2012
9	Vascular Diseases (Vascular Disease) 07/2019 - 04/2003
9	Inflammation (Inflammations) 04/2018 - 02/2003
9	Myocardial Ischemia (Ischemic Heart Diseases) 10/2017 - 07/2002
8	Hemorrhagic Stroke 01/2021 - 08/2014
6	Neoplasms (Cancer) 01/2022 - 05/2002
6	Chronic Renal Insufficiency 01/2021 - 12/2004
6	Necrosis 03/2019 - 05/2005
6	Renal Insufficiency (Renal Failure) 02/2019 - 02/2003
6	Thromboembolism 01/2019 - 09/2010

Drug/Important Bio-Agent (IBA)

47	Biomarkers (Surrogate Marker)IBA 11/2021 - 04/2002
44	Warfarin (Coumadin)FDA LinkGeneric 09/2022 - 09/2010
41	edoxabanIBA 09/2022 - 10/2010
39	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 03/2022 - 04/2004
39	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2021 - 09/2002
36	Clopidogrel (Plavix)FDA Link 01/2020 - 08/2004
31	Brain Natriuretic Peptide (Natrecor)FDA Link 11/2021 - 02/2002
30	Factor Xa (Coagulation Factor Xa)IBA 04/2021 - 10/2010
28	Prasugrel Hydrochloride FDA Link 01/2020 - 06/2005
27	Glycoproteins (Glycoprotein)IBA 01/2018 - 11/2002
27	Pravastatin (Pravachol)FDA LinkGeneric 06/2011 - 03/2002
25	Atorvastatin (Lipitor)FDA Link 07/2019 - 04/2002
23	Heparin (Liquaemin)FDA LinkGeneric 09/2010 - 02/2002
22	Simvastatin (Zocor)FDA LinkGeneric 10/2021 - 09/2004
22	TicagrelorIBA 01/2021 - 04/2014
22	Enoxaparin (Lovenox)FDA LinkGeneric 07/2013 - 04/2002
21	C-Reactive ProteinIBA 01/2019 - 04/2002
21	Tirofiban (Aggrastat)FDA Link 09/2008 - 07/2002
20	Ezetimibe (Zetia)FDA Link 10/2021 - 08/2014
20	AnticoagulantsIBA 02/2021 - 03/2005
20	Troponin IIBA 12/2018 - 04/2002
19	vorapaxarIBA 01/2018 - 09/2009
18	saxagliptin FDA Link 11/2021 - 11/2011
17	LipidsIBA 03/2022 - 04/2003
16	sacubitril and valsartan sodium hydrate drug combinationIBA 01/2022 - 03/2015
16	Neurofibromin 2 (Merlin)IBA 10/2015 - 06/2006
16	Ranolazine FDA Link 01/2015 - 06/2006
15	LDL CholesterolIBA 11/2020 - 03/2002
15	TroponinIBA 11/2020 - 09/2003
14	oxidized low density lipoproteinIBA 03/2022 - 03/2002
14	Pharmaceutical PreparationsIBA 11/2020 - 02/2002
13	pro-brain natriuretic peptide (1-76)IBA 01/2022 - 07/2007
13	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 06/2006
12	CreatinineIBA 01/2022 - 11/2003
12	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2022 - 11/2004
12	Simvastatin Drug Combination Ezetimibe (Vytorin)FDA Link 10/2021 - 11/2008
12	RivaroxabanIBA 03/2019 - 05/2011
11	Factor Xa InhibitorsIBA 03/2019 - 10/2010
11	Eptifibatide (Integrilin)FDA Link 04/2014 - 04/2003
10	Troponin T (Troponin T1)IBA 11/2021 - 09/2002
10	Vitamin K FDA Link 01/2021 - 10/2010
10	Enalapril FDA LinkGeneric 01/2021 - 01/2018
10	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 06/2014 - 11/2004
10	N(2)-(3-trifluoromethylphenyl)guanineIBA 04/2014 - 04/2002
9	omega-Chloroacetophenone (Mace)IBA 01/2020 - 06/2006
9	DiureticsIBA 12/2018 - 03/2011
9	Thrombin Receptors (Thrombin Receptor)IBA 01/2018 - 12/2014
9	Natriuretic PeptidesIBA 01/2018 - 11/2004
9	AntithrombinsIBA 08/2011 - 04/2002
8	thienopyridineIBA 01/2016 - 11/2007
7	Neprilysin (Neutral Endopeptidase)IBA 10/2022 - 03/2015
7	Valsartan (Vals)FDA Link 01/2022 - 08/2010
7	darapladibIBA 01/2021 - 10/2011
7	trandolapril (Mavik)FDA LinkGeneric 01/2019 - 11/2004
7	Tenecteplase FDA Link 07/2005 - 04/2003
6	Thrombin FDA Link 03/2019 - 06/2006
6	1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase)IBA 01/2018 - 04/2006

Therapy/Procedure

167	Therapeutics 03/2022 - 03/2002
46	Percutaneous Coronary Intervention 12/2021 - 04/2002
25	Stents 12/2021 - 11/2007
21	Thrombolytic Therapy 01/2021 - 10/2002
21	Secondary Prevention 01/2020 - 03/2005
20	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 12/2021 - 12/2002
18	Patient Readmission 01/2021 - 09/2002